Ready or not, there will be another Manning-James backfield in the NFL coming soon ... so says Edgerrin James, who's guaranteeing to TMZ Sports that it will happen!!!

James told TMZ Sports in NYC that he believes his son, Eden James, and Peyton Manning's nephew, Arch Manning, will rekindle the legendary James-Manning connection in the league in just a few years.

"I'm calling it right now," Edgerrin said. "They're both going to be in the NFL together. The next wave -- 2.0!"

Edgerrin, whose son will be a freshman running back on the Howard Univ. football team this year, made the promise just hours after Arch, the top-ranked QB in the 2023 H.S. class, committed to Texas.

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