49ers running back Isaac Guerendo did not practice on Wednesday according to the team's official website.

Guerendo played through a foot injury last week. He was listed as questionable for the Thursday tilt, played, and saw all 16 of the team’s running back carries.  Now he is also battling a hamstring injury that likely didn't appear until after the team's Week 15 loss to the Rams. 

If he can’t suit up this week, the 49ers will be down to their fifth-string running back Patrick Taylor. San Francisco called him up from the practice squad after both Christian McCaffrey and Jordan Mason went on injured reserve. Taylor is worth an add in all leagues, though we should expect to see some Israel Abanikanda and possibly Ke’Shawn Vaughn if Guerendo is out.