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Massachusetts NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2019 | 2 | 62 | Andy Isabella | Cardinals | WR | Massachusetts |
| 2016 | 5 | 140 | Tajae Sharpe | Titans | WR | Massachusetts |
| 2014 | 7 | 230 | Rob Blanchflower | Steelers | TE | Massachusetts |
| 2013 | 7 | 253 | Michael Cox | Giants | RB | Massachusetts |
| 2010 | 2 | 61 | Vladimir Ducasse | Jets | OT | Massachusetts |
| 1999 | 5 | 144 | Khari Samuel | Bears | LB | Massachusetts |
| 1980 | 10 | 252 | Sandro Vitello | Bengals | K | Massachusetts |
| 1979 | 7 | 192 | Bruce Kimball | Steelers | OG | Massachusetts |
| 1976 | 8 | 237 | Ed McAleney | Steelers | DT | Massachusetts |
| 1975 | 10 | 244 | William Cooke | Packers | DE | Massachusetts |
| 1974 | 15 | 379 | Peil Pennington | Broncos | QB | Massachusetts |
| 1974 | 17 | 421 | Tim Berra | Colts | WR | Massachusetts |
| 1973 | 13 | 329 | Paul Metallo | Chiefs | DB | Massachusetts |
| 1972 | 15 | 368 | John Hulecki | Steelers | OG | Massachusetts |
| 1972 | 15 | 370 | Harold Parmenter | Broncos | DT | Massachusetts |
| 1971 | 4 | 92 | Robert Pena | Browns | OG | Massachusetts |
| 1971 | 15 | 365 | Nick McGarry | Patriots | TE | Massachusetts |
| 1970 | 16 | 403 | Steve Parnell | Falcons | WR | Massachusetts |
| 1968 | 1 | 11 | Greg Landry | Lions | QB | Massachusetts |
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