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Northern Iowa NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2022 | 1 | 19 | Trevor Penning | Saints | OT | Northern Iowa |
| 2021 | 3 | 93 | Spencer Brown | Bills | OT | Northern Iowa |
| 2021 | 4 | 116 | Ellerson Smith | Giants | LB | Northern Iowa |
| 2018 | 5 | 159 | Daurice Fountain | Colts | WR | Northern Iowa |
| 2016 | 4 | 127 | Deiondre Hall | Bears | S | Northern Iowa |
| 2015 | 3 | 86 | David Johnson | Cardinals | RB | Northern Iowa |
| 2008 | 3 | 96 | Chad Rinehart | Commanders | OG | Northern Iowa |
| 2008 | 7 | 225 | Brandon Keith | Cardinals | OT | Northern Iowa |
| 2002 | 5 | 169 | Ryan Hannam | Seahawks | TE | Northern Iowa |
| 2001 | 5 | 159 | Eddie Berlin | Titans | WR | Northern Iowa |
| 2000 | 2 | 60 | Brad Meester | Jaguars | C | Northern Iowa |
| 1999 | 5 | 137 | Tyree Talton | Lions | DB | Northern Iowa |
| 1997 | 3 | 88 | Dedric Ward | Jets | WR | Northern Iowa |
| 1993 | 5 | 129 | Kenny Shedd | Jets | WR | Northern Iowa |
| 1991 | 3 | 57 | James Jones | Browns | DT | Northern Iowa |
| 1990 | 6 | 159 | Bryce Paup | Packers | LB | Northern Iowa |
| 1982 | 11 | 296 | Steve Sandon | Patriots | QB | Northern Iowa |
| 1976 | 10 | 289 | Bill Salmon | Vikings | QB | Northern Iowa |
| 1976 | 16 | 440 | Mike Timmermans | Packers | OG | Northern Iowa |
| 1968 | 17 | 458 | Roy Pederson | Colts | LB | Northern Iowa |
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