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Eastern Illinois NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2014 | 2 | 62 | Jimmy Garoppolo | Patriots | QB | Eastern Illinois |
| 2010 | 5 | 152 | Otis Hudson | Bengals | OG | Eastern Illinois |
| 1999 | 3 | 67 | Chris Watson | Broncos | DB | Eastern Illinois |
| 1995 | 4 | 114 | Ray McElroy | Colts | DB | Eastern Illinois |
| 1993 | 7 | 179 | Brad Fichtel | Rams | C | Eastern Illinois |
| 1989 | 7 | 175 | Dave Popp | Giants | OT | Eastern Illinois |
| 1987 | 5 | 114 | Roy Banks | Colts | WR | Eastern Illinois |
| 1983 | 5 | 137 | Jeff Christensen | Bengals | QB | Eastern Illinois |
| 1980 | 8 | 220 | Tom Pettigrew | Rams | OT | Eastern Illinois |
| 1977 | 4 | 93 | Ted Petersen | Steelers | C | Eastern Illinois |
| 1974 | 16 | 411 | Nate Anderson | Commanders | RB | Eastern Illinois |
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