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Illinois State NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2013 | 6 | 193 | Nate Palmer | Packers | LB | Illinois State |
| 2007 | 3 | 75 | Laurent Robinson | Falcons | WR | Illinois State |
| 2006 | 5 | 160 | Brent Hawkins | Jaguars | DE | Illinois State |
| 2005 | 5 | 138 | Boomer Grigsby, | Chiefs | LB | Illinois State |
| 1990 | 10 | 258 | Bill Miller | Lions | WR | Illinois State |
| 1986 | 7 | 167 | Jim Meyer | Browns | OT | Illinois State |
| 1985 | 7 | 176 | Mike Prior | Buccaneers | DB | Illinois State |
| 1978 | 3 | 62 | Estus Hood | Packers | DB | Illinois State |
| 1976 | 6 | 172 | Calvin Harper | Chiefs | OT | Illinois State |
| 1973 | 6 | 140 | Ron Bell | Steelers | RB | Illinois State |
| 1970 | 15 | 385 | Guy Homoly | Browns | DB | Illinois State |
| 1969 | 3 | 77 | Dennis Nelson | Colts | OT | Illinois State |
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