| Date | Opponent | Stadium | Time |
| 9/9/2019 | @ Oakland | Oakland Coliseum | 10:20:00 PM |
| 9/15/2019 | Chicago | Broncos Stadium at Mile High | 4:25:00 PM |
| 9/22/2019 | @ Green Bay | Lambeau Field | 1:00:00 PM |
| 9/29/2019 | Jacksonville | Broncos Stadium at Mile High | 4:25:00 PM |
| 10/6/2019 | @ L.A. Chargers | StubHub Center | 4:05:00 PM |
| 10/13/2019 | Tennessee | Broncos Stadium at Mile High | 4:25:00 PM |
| 10/17/2019 | Kansas City | Broncos Stadium at Mile High | 8:20:00 PM |
| 10/27/2019 | @ Indianapolis | Lucas Oil Stadium | 4:25:00 PM |
| 11/3/2019 | Cleveland | Broncos Stadium at Mile High | 4:25:00 PM |
| | BYE | | |
| 11/17/2019 | @ Minnesota | U.S. Bank Stadium | 1:00:00 PM |
| 11/24/2019 | @ Buffalo | New Era Field | 1:00:00 PM |
| 12/1/2019 | L.A. Chargers | Broncos Stadium at Mile High | 4:25:00 PM |
| 12/8/2019 | @ Houston | NRG Stadium | 1:00:00 PM |
| 12/15/2019 | @ Kansas City | Arrowhead Stadium | 1:00:00 PM |
| 12/22/2019 | Detroit | Broncos Stadium at Mile High | TBA |
| 12/29/2019 | Oakland | Broncos Stadium at Mile High | 4:25:00 PM |