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Purdue NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2024 | 5 | 166 | Tyrone Tracy Jr. | Giants | RB | Purdue |
| 2023 | 4 | 131 | Charlie Jones | Bengals | WR | Purdue |
| 2023 | 4 | 135 | Aidan O'Connell | Raiders | QB | Purdue |
| 2023 | 5 | 171 | Payne Durham | Buccaneers | TE | Purdue |
| 2023 | 7 | 241 | Cory Trice Jr. | Steelers | CB | Purdue |
| 2023 | 7 | 255 | Jalen Graham | 49ers | LB | Purdue |
| 2022 | 1 | 30 | George Karlaftis | Chiefs | Purdue | Purdue |
| 2022 | 3 | 99 | David Bell | Browns | WR | Purdue |
| 2022 | 7 | 260 | Zander Horvath | Chargers | FB | Purdue |
| 2021 | 2 | 49 | Rondale Moore | Cardinals | WR | Purdue |
| 2021 | 4 | 113 | Derrick Barnes | Lions | LB | Purdue |
| 2020 | 4 | 136 | Brycan Hopkins | Rams | TE | Purdue |
| 2020 | 7 | 215 | Markus Bailey | Bengals | LB | Purdue |
| 2018 | 5 | 143 | J'Whaun Bentley | Patriots | LB | Purdue |
| 2017 | 5 | 175 | DeAngelo Yancey | Packers | WR | Purdue |
| 2016 | 6 | 189 | Anthony Brown | Cowboys | CB | Purdue |
| 2015 | 5 | 163 | Ryan Russell | Cowboys | DE | Purdue |
| 2014 | 5 | 147 | Ricardo Allen | Falcons | CB | Purdue |
| 2014 | 5 | 149 | Kevin Pamphile | Buccaneers | OT | Purdue |
| 2013 | 2 | 44 | Kawann Short | Panthers | DT | Purdue |
| 2012 | 5 | 153 | Dennis Kelly | Eagles | OT | Purdue |
| 2012 | 6 | 195 | Nick Mondek | Texans | OT | Purdue |
| 2011 | 1 | 16 | Ryan Kerrigan | Commanders | DE | Purdue |
| 2010 | 2 | 56 | Mike Neal | Packers | DT | Purdue |
| 2009 | 3 | 67 | Alex Magee | Chiefs | DE | Purdue |
| 2009 | 6 | 201 | Curtis Painter | Colts | QB | Purdue |
| 2008 | 1 | 30 | Dustin Keller | Jets | TE | Purdue |
| 2008 | 3 | 92 | Cliff Avril | Lions | DE | Purdue |
| 2008 | 4 | 134 | Stanford Keglar | Titans | OLB | Purdue |
| 2007 | 1 | 26 | Anthony Spencer | Cowboys | DE | Purdue |
| 2007 | 5 | 149 | Uche Nwaneri | Jaguars | OG | Purdue |
| 2007 | 7 | 223 | Mike Otto | Titans | OT | Purdue |
| 2006 | 2 | 54 | Bernard Pollard | Chiefs | S | Purdue |
| 2006 | 4 | 127 | Ray Edwards | Vikings | DE | Purdue |
| 2006 | 5 | 135 | Rob Ninkovich | Saints | DE | Purdue |
| 2006 | 5 | 167 | Charles Davis | Steelers | TE | Purdue |
| 2005 | 4 | 106 | Kyle Orton | Bears | QB | Purdue |
| 2004 | 3 | 66 | Nick Hardwick | Chargers | C | Purdue |
| 2004 | 3 | 67 | Stuart Schweigert | Raiders | S | Purdue |
| 2004 | 3 | 69 | Gilbert Gardner | Colts | LB | Purdue |
| 2004 | 3 | 96 | Landon Johnson | Bengals | LB | Purdue |
| 2004 | 4 | 98 | Shaun Phillips | Chargers | DE | Purdue |
| 2004 | 4 | 116 | Niko Koutouvides | Seahawks | LB | Purdue |
| 2004 | 6 | 172 | Kelly Butler | Lions | OT | Purdue |
| 2004 | 6 | 189 | Craig Terrill | Seahawks | DT | Purdue |
| 2004 | 7 | 223 | Jacques Reeves | Cowboys | CB | Purdue |
| 2003 | 6 | 191 | Joe Odom | Bears | LB | Purdue |
| 2002 | 3 | 89 | Akinola Avodele | Jaguars | LB | Purdue |
| 2002 | 4 | 109 | Travis Dorsch | Bengals | K | Purdue |
| 2001 | 2 | 32 | Drew Brees | Chargers | QB | Purdue |
| 2001 | 2 | 48 | Matt Light | Patriots | OT | Purdue |
| 2001 | 5 | 136 | Vinny Sutherland | Falcons | WR | Purdue |
| 2001 | 5 | 146 | Chukky Okabi | Steelers | C | Purdue |
| 2001 | 7 | 201 | Brandon Gorin | Chargers | OT | Purdue |
| 2000 | 6 | 195 | Michael Hawthorne | Saints | DB | Purdue |
| 2000 | 6 | 201 | David Nugent | Patriots | DT | Purdue |
| 1999 | 3 | 89 | Chike Okeafor | 49ers | DE | Purdue |
| 1999 | 4 | 111 | Rosevelt Colvin | Bears | DE | Purdue |
| 1998 | 3 | 70 | Brian Alford | Giants | WR | Purdue |
| 1998 | 5 | 140 | Mark Fischer | Commanders | OG | Purdue |
| 1998 | 7 | 218 | Edwin Watson | Packers | RB | Purdue |
| 1998 | 7 | 224 | Ernest Blackwell | Chiefs | RB | Purdue |
| 1996 | 2 | 35 | Mike Alstott | Buccaneers | RB | Purdue |
| 1995 | 6 | 175 | Ryan Grigson | Bengals | OT | Purdue |
| 1993 | 7 | 185 | Jeff Zgonina | Steelers | DT | Purdue |
| 1992 | 4 | 111 | Frank Kmet | Bills | DE | Purdue |
| 1991 | 3 | 71 | Steve Jackson | Oilers | DB | Purdue |
| 1991 | 5 | 118 | Scott Conover | Lions | OG | Purdue |
| 1990 | 5 | 133 | Calvin Williams | Eagles | WR | Purdue |
| 1990 | 8 | 202 | Bill Hitchcock | Seahawks | OT | Purdue |
| 1990 | 11 | 279 | Derrick Kelson | Jets | DB | Purdue |
| 1990 | 12 | 305 | Shawn McCarthy | Falcons | P | Purdue |
| 1989 | 4 | 91 | Jerrol Williams | Steelers | LB | Purdue |
| 1988 | 2 | 47 | Fred Stickland | Rams | LB | Purdue |
| 1988 | 5 | 125 | Cris Dishman | Oilers | DB | Purdue |
| 1987 | 1 | 10 | Rod Woodson | Steelers | DB | Purdue |
| 1986 | 1 | 3 | Jim Everett | Oilers | QB | Purdue |
| 1986 | 6 | 145 | Ray Wallace | Oilers | RB | Purdue |
| 1986 | 6 | 161 | Mark Jackson | Broncos | WR | Purdue |
| 1986 | 7 | 175 | Rodney Carter | Steelers | RB | Purdue |
| 1986 | 11 | 279 | Mark Drenth | Buccaneers | OT | Purdue |
| 1986 | 12 | 308 | Steve Griffin | Falcons | WR | Purdue |
| 1985 | 2 | 32 | Don Anderson | Colts | DB | Purdue |
| 1985 | 5 | 126 | Bruce King | Chiefs | RB | Purdue |
| 1984 | 3 | 66 | Chris Scott | Colts | DT | Purdue |
| 1984 | 5 | 132 | Cliff Benson | Falcons | TE | Purdue |
| 1984 | 7 | 191 | Scott Campbell | Steelers | QB | Purdue |
| 1983 | 8 | 210 | Matt Hernandez | Seahawks | OT | Purdue |
| 1983 | 9 | 250 | Mark Brown | Dolphins | LB | Purdue |
| 1982 | 4 | 94 | Steve Bryant | Oilers | WR | Purdue |
| 1982 | 8 | 217 | Jim Fritzche | Eagles | OT | Purdue |
| 1982 | 10 | 266 | Roosevelt Barnes | Lions | LB | Purdue |
| 1981 | 2 | 32 | Dave Young | Giants | TE | Purdue |
| 1981 | 4 | 98 | Mark Herrmann | Broncos | QB | Purdue |
| 1981 | 5 | 135 | Calvin Clark | Bills | DE | Purdue |
| 1981 | 6 | 159 | Bill Kay | Oilers | DB | Purdue |
| 1980 | 2 | 39 | Keena Turner | 49ers | LB | Purdue |
| 1980 | 11 | 278 | Wayne Smith | Lions | DB | Purdue |
| 1980 | 12 | 321 | Marcus Jackson | Browns | DT | Purdue |
| 1979 | 8 | 203 | Rick Moss | Bears | DB | Purdue |
| 1978 | 6 | 139 | John Skibinski | Bears | RB | Purdue |
| 1978 | 10 | 262 | Fred Arrington | Lions | LB | Purdue |
| 1977 | 4 | 89 | Scott Dierking | Jets | RB | Purdue |
| 1977 | 5 | 118 | Dave Lafary | Saints | OT | Purdue |
| 1977 | 7 | 184 | Blane Smith | Browns | TE | Purdue |
| 1977 | 9 | 246 | Mike Northington | Commanders | RB | Purdue |
| 1977 | 10 | 261 | Mark Vitali | Chiefs | QB | Purdue |
| 1977 | 11 | 294 | Connie Zelencik | Bears | C | Purdue |
| 1976 | 1 | 7 | Mike Pruitt | Browns | RB | Purdue |
| 1976 | 1 | 20 | Ken Novak | Colts | DT | Purdue |
| 1976 | 2 | 44 | Ken Long | Lions | OG | Purdue |
| 1976 | 9 | 261 | Craig Nagel | Browns | QB | Purdue |
| 1976 | 10 | 286 | Dwight Lewis | Raiders | DB | Purdue |
| 1976 | 14 | 401 | Jeff Stapleton | Vikings | OT | Purdue |
| 1975 | 1 | 7 | Larry Burton | Saints | WR | Purdue |
| 1975 | 6 | 138 | Fred Cooper | Lions | DB | Purdue |
| 1975 | 8 | 186 | Barry Santini | Browns | TE | Purdue |
| 1975 | 8 | 206 | Ralph Peratta | Chargers | OG | Purdue |
| 1974 | 5 | 117 | Carl Capria | Lions | DB | Purdue |
| 1974 | 7 | 163 | Bob Herrick | Browns | WR | Purdue |
| 1974 | 8 | 204 | Mark Gefert | Steelers | LB | Purdue |
| 1974 | 12 | 307 | Bob Bobrowski | Colts | QB | Purdue |
| 1973 | 1 | 5 | Dave Butz | Cardinals | DT | Purdue |
| 1973 | 1 | 9 | Otis Armstrong | Broncos | RB | Purdue |
| 1973 | 1 | 19 | Darryl Stingley | Patriots | WR | Purdue |
| 1973 | 2 | 48 | Gary Hrivnak | Bears | DT | Purdue |
| 1973 | 2 | 51 | Steve Barmgartner | Saints | DE | Purdue |
| 1973 | 4 | 79 | Greg Bingham | Oilers | LB | Purdue |
| 1973 | 6 | 153 | Brent Myers | Raiders | OT | Purdue |
| 1973 | 7 | 173 | Don Smith | Chiefs | OT | Purdue |
| 1972 | 3 | 68 | Tom Luken | Eagles | OG | Purdue |
| 1972 | 6 | 145 | Charles Potts | Lions | DB | Purdue |
| 1972 | 10 | 249 | Jim Teal | Lions | LB | Purdue |
| 1972 | 12 | 311 | Ashley Bell | Dolphins | TE | Purdue |
| 1971 | 5 | 107 | Don Green | Bills | OT | Purdue |
| 1971 | 5 | 118 | Stan Brown | Browns | WR | Purdue |
| 1971 | 9 | 217 | John Handy | Broncos | LB | Purdue |
| 1971 | 10 | 255 | Ron Maree | Dolphins | DT | Purdue |
| 1971 | 13 | 335 | John Bullock | 49ers | RB | Purdue |
| 1970 | 1 | 3 | Mike Phipps | Browns | QB | Purdue |
| 1970 | 3 | 55 | Tim Foley | Dolphins | DB | Purdue |
| 1970 | 5 | 115 | Bill McKoy | Broncos | LB | Purdue |
| 1970 | 9 | 212 | Dennis Wirgowski | Patriots | DE | Purdue |
| 1970 | 10 | 255 | Bill Yanchar | Browns | DT | Purdue |
| 1970 | 15 | 384 | Tom Bayless | Jets | DT | Purdue |
| 1969 | 1 | 3 | Leroy Keyes | Eagles | RB | Purdue |
| 1969 | 4 | 90 | Perry Williams | Packers | RB | Purdue |
| 1969 | 5 | 125 | Chuck Kyle | Cowboys | LB | Purdue |
| 1969 | 8 | 204 | Clanton King | Chiefs | OT | Purdue |
| 1969 | 10 | 259 | Marion Griffin | Colts | TE | Purdue |
| 1969 | 11 | 286 | Gary Roberts | Jets | OG | Purdue |
| 1969 | 16 | 403 | Dave Stydahar | Bears | OG | Purdue |
| 1968 | 3 | 65 | Lance Olssen | 49ers | OT | Purdue |
| 1968 | 4 | 105 | Jim Beirne | Oilers | OT | Purdue |
| 1967 | 1 | 4 | Bob Griese | Dolphins | QB | Purdue |
| 1967 | 1 | 21 | John Charles | Patriots | DB | Purdue |
| 1967 | 8 | 194 | Mike Barnes | Steelers | OT | Purdue |
| 1967 | 14 | 359 | Pat Conley | Colts | LB | Purdue |
| 1967 | 17 | 437 | George Catavolos | Eagles | DB | Purdue |
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