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Southeast Missouri State NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2024 | 6 | 216 | Ryan Flournoy | Cowboys | WR | Southeast Missouri State |
| 2018 | 7 | 248 | Kendall Donnerson | Packers | DE | Southeast Missouri State |
| 2003 | 6 | 199 | Willie Ponder | Giants | WR | Southeast Missouri State |
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