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Texas Southern NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2015 | 4 | 136 | Tray Walker | Ravens | CB | Texas Southern |
| 2000 | 5 | 151 | Joey Jamison | Packers | WR | Texas Southern |
| 1997 | 5 | 157 | Nick Lopez | Dolphins | DE | Texas Southern |
| 1995 | 7 | 223 | Jessie Cox | Colts | LB | Texas Southern |
| 1994 | 3 | 90 | Joe Burch | Patriots | C | Texas Southern |
| 1993 | 2 | 40 | Michael Strahan | Giants | DE | Texas Southern |
| 1993 | 4 | 86 | Kevin Johnson | Patriots | DT | Texas Southern |
| 1992 | 5 | 120 | Greg Briggs | Cowboys | DB | Texas Southern |
| 1992 | 10 | 268 | Alberto White | Raiders | DE | Texas Southern |
| 1991 | 4 | 110 | Kevin Harris | Cowboys | DE | Texas Southern |
| 1983 | 6 | 148 | Rheugene Branton | Buccaneers | WR | Texas Southern |
| 1983 | 12 | 308 | Carl Williams | Colts | WR | Texas Southern |
| 1980 | 12 | 322 | Calvin Muhammad | Raiders | WR | Texas Southern |
| 1976 | 2 | 34 | Charles Philyaw | Raiders | DT | Texas Southern |
| 1976 | 3 | 88 | Ernest Pough | Steelers | WR | Texas Southern |
| 1975 | 12 | 289 | Alonza Picket | Falcons | OT | Texas Southern |
| 1975 | 15 | 377 | Jack Holmes | Oilers | RB | Texas Southern |
| 1974 | 8 | 208 | Melvin Baker | Dolphins | WR | Texas Southern |
| 1974 | 11 | 279 | Harold Hart | Raiders | RB | Texas Southern |
| 1973 | 1 | 18 | Mike Holmes | 49ers | DB | Texas Southern |
| 1973 | 16 | 402 | Larry Smiley | Vikings | DE | Texas Southern |
| 1972 | 6 | 151 | Edward Hebert | Rams | DT | Texas Southern |
| 1971 | 2 | 27 | Julius Adams | Patriots | DT | Texas Southern |
| 1971 | 8 | 184 | Larry Crowe | Steelers | RB | Texas Southern |
| 1971 | 8 | 203 | Ernie Holmes | Steelers | DT | Texas Southern |
| 1971 | 11 | 276 | Nate Allen | Chiefs | DB | Texas Southern |
| 1971 | 13 | 333 | Lionel Hepburn | Dolphins | DB | Texas Southern |
| 1971 | 13 | 337 | James Ford | Cowboys | RB | Texas Southern |
| 1970 | 1 | 10 | Ken Burrough | Saints | WR | Texas Southern |
| 1970 | 9 | 222 | Charlie Blossom | Oilers | DE | Texas Southern |
| 1970 | 14 | 340 | Bert Askon | Steelers | LB | Texas Southern |
| 1969 | 2 | 28 | Ernest Calloway | Eagles | LB | Texas Southern |
| 1969 | 6 | 148 | Marion Bates | Vikings | DB | Texas Southern |
| 1969 | 16 | 393 | Ed Hughes | Falcons | RB | Texas Southern |
| 1969 | 16 | 401 | Lloyd Mumford | Dolphins | DB | Texas Southern |
| 1968 | 13 | 328 | James Bivins | Bengals | LB | Texas Southern |
| 1968 | 15 | 392 | Roger Coverson | Commanders | OG | Texas Southern |
| 1968 | 17 | 456 | Wesley Williams | Chiefs | LB | Texas Southern |
| 1967 | 2 | 33 | Willie Ellison | Rams | RB | Texas Southern |
| 1967 | 2 | 49 | Roy Hopkins | Oilers | RB | Texas Southern |
| 1967 | 5 | 133 | John Douglas | Saints | DB | Texas Southern |
| 1967 | 11 | 283 | Leroy Mitchell | Patriots | WR | Texas Southern |
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