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William & Mary NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2023 | 5 | 152 | Colby Sorsdal | Lions | OT | William & Mary |
| 2016 | 6 | 185 | DeAndre Houston-Carson | Bears | FS | William & Mary |
| 2015 | 7 | 245 | Tre McBride | Titans | WR | William & Mary |
| 2013 | 4 | 114 | BW Webb | Cowboys | CB | William & Mary |
| 2010 | 6 | 184 | Arian Tracy | Giants | LB | William & Mary |
| 2010 | 7 | 234 | Sean Lissemore | Cowboys | DT | William & Mary |
| 2009 | 3 | 73 | Derek Cox | Jaguars | CB | William & Mary |
| 1997 | 2 | 60 | Darren Sharper | Packers | DB | William & Mary |
| 1992 | 4 | 112 | Chris Hakel | Commanders | QB | William & Mary |
| 1991 | 7 | 170 | Tyrone Shelton | Rams | RB | William & Mary |
| 1987 | 7 | 193 | Archie Harris | Bears | OT | William & Mary |
| 1987 | 8 | 218 | Michael Clemons | Chiefs | RB | William & Mary |
| 1987 | 9 | 232 | Ken Lambiotte | Eagles | QB | William & Mary |
| 1985 | 10 | 261 | Mark Kelso | Eagles | DB | William & Mary |
| 1982 | 3 | 83 | John Cannon | Buccaneers | DE | William & Mary |
| 1976 | 16 | 447 | Craig McCurdy | Lions | LB | William & Mary |
| 1975 | 12 | 298 | Richard Pawlewicz | Eagles | RB | William & Mary |
| 1974 | 16 | 405 | Barry Beers | Chiefs | OG | William & Mary |
| 1973 | 11 | 272 | David Knight | Jets | WR | William & Mary |
| 1972 | 14 | 358 | Dennis Cambal | Raiders | RB | William & Mary |
| 1972 | 15 | 389 | Bill Davis | Dolphins | DT | William & Mary |
| 1971 | 15 | 383 | Andy Giles | Raiders | DE | William & Mary |
| 1968 | 13 | 336 | Dan Darragh | Bills | QB | William & Mary |
| 1968 | 16 | 412 | Adin Brown | Broncos | LB | William & Mary |
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