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San Francisco 49ers 2021 NFL Schedule

Regular Season
DateOpponentStadiumTime
Sun, Sep 12@ Detroit 1:00 PM
Sun, Sep 19@ Philadelphia 1:00 PM
Sun, Sep 26vs Green Bay 8:20 PM
Sun, Oct 3vs Seattle 4:05 PM
Sun, Oct 10@ Arizona 4:25 PM
BYE WEEK   
Sun, Oct 24vs Indianapolis 8:20 PM
Sun, Oct 31@ Chicago 1:00 PM
Sun, Nov 7vs Arizona 4:25 PM
Mon, Nov 15vs Los Angeles Rams 8:15 PM
Sun, Nov 21@ Jacksonville 1:00 PM
Sun, Nov 28vs Minnesota 4:25 PM
Sun, Dec 5@ Seattle 8:20 PM
Sun, Dec 12@ Cincinnati 1:00 PM
Sun, Dec 19vs Atlanta 4:05 PM
Thu, Dec 23@ Tennessee 8:20 PM
Sun, Jan 2vs Houston 4:05 PM
Sun, Jan 9@ Los Angeles Rams 4:25 PM